October 28 – Holmes at Northeast
October 21 – MS Delta at Holmes
October 14 – Holmes at Itawamba
October 7 – Holmes at Pearl River
September 30 – Coahoma at Holmes
September 23 – Holmes at East Mississippi
September 16, 2021 – Northwest at Holmes
September 9, 2021 – Holmes at Hinds
September 2, 2021 – MS Gulf Coast at Holmes
